Studies on the Antihypertensive Effect of Abana in Rats

Treatment with Abana (3 g/kg/day, p.o) for 3 weeks, reduced the blood pressure of unilaterally nephrectomized DOCAsalt-treated hypertensive rats. Similar reduction in blood pressure was also observed in the CdCh (1 mg/kg/day, i.p. for two weeks) treated hypertensive rats. The pressor response to adrenaline and noradrenaline (1 and 2 μg/kg) was reduced by chronic administration of Abana in these hypertensive animals. However, Abana (3 g/kg/day, p.o) administered to normotensive female albino rats for 3 weeks did not alter the mean blood pressure and the pressor response to adrenaline and noradrenaline (1 and 2 μg/kg). The vascular reactivity to noradrenaline in isolated aortic strip and portal vein was also reduced by the chronic administration of Abana in the hypertensive rats. It is concluded that the antihypertensive effect of Abana might be due to its alteration of cation transport into the cell.